Genes, Free Full-Text
By A Mystery Man Writer
Description
Breast cancer is the most common women’s malignancy in the world and, for subgroups of patients, treatment outcomes remain poor. Thus, more effective therapeutic strategies are urgently needed. MicroRNAs (miRNAs) have emerged as promising therapeutic tools and targets, as they play significant roles in regulating key cellular processes by suppressing gene expression. However, additive opportunities involving miRNAs have been underexplored. For example, both miR-34a and miR-200c individually suppress the development of different types of cancer, but the cellular effects of their combined actions remain unknown. Here, we show that miR-34a and miR-200c levels are reduced in breast tumors compared to adjacent normal tissues and that this additively predicts poor patient survival. In addition, in cell lines, miR-34a and miR-200c additively induce apoptosis and cell cycle arrest, while also inhibiting proliferation, invasion, migration, stemness and epithelial-to-mesenchymal transition (EMT). Mechanistically, both miRNA-34a and miR-200c directly target HIF1-α and subsequently downregulate VEGFR, MMP9 and CXCR4, although combined miRNA-34a and miR-200c delivery suppresses mouse xenograft tumor development as effectively as individual delivery. We establish a model, supported by in vitro and clinical data, which collectively suggest that the co-delivery of miR-34a and miR-200c represents a promising novel therapeutic strategy for breast cancer patients.
Genes, Free Full-Text
Upload Raw DNA Data & Get Free Analysis
Genes, Free Full-Text, overloaded tradução
Gene, Definition, Structure, Expression, & Facts
Computing the family-free DCJ similarity, BMC Bioinformatics
Solved 10. A cell that is capable of importing free DNA into
Genes, Free Full-Text
Relapse free survival Kaplan Meier curves of all four genes
Mapping of late adenovirus genes by cell-free translation of RNA selected by hybridization to specific DNA fragments. - Abstract - Europe PMC
How To Get Your Genetic Data (For Free) And Interpret Your Genes!
Free DNA Upload Sites, DNA Sites for Raw Data Uploads
PPT - Genome annotation PowerPoint Presentation, free download - ID:900100
from
per adult (price varies by group size)