Mitotane (2,4′-DDD), Antineoplastic Agent
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Description
Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions. - Mechanism of Action & Protocol.
The effect of mitotane on viability, steroidogenesis and gene expression in NCI‑H295R adrenocortical cells
The Challenging Pharmacokinetics of Mitotane: An Old Drug in Need of New Packaging
Exposure to anticancer drugs modulates the expression of ACSL4 and ABCG2 proteins in adrenocortical carcinoma cells - ScienceDirect
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Frontiers Complete Remission of Advanced Adrenocortical Cancer Following Mitotane Monotherapy: A Case Report and Literature Review of Predictive Markers
The Challenging Pharmacokinetics of Mitotane: An Old Drug in Need of New Packaging
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Viability and apoptosis of H295R cells treated with mitotane and/or
Potentiation of mitotane action by rosuvastatin: New insights for adrenocortical carcinoma management
Mitotane induces drug metabolism genes in human liver. HepaRG cells (A
Mitotane - Wikipedia
Chemical Name : Mitotane-d4
Cancers, Free Full-Text
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